Research on the Combination of Commercially Available Thickeners and Nutritional Supplemental Drink -Aiming At the Care Food That Can Be Done In the General Family-

Publication Information
ISSN: 2641-6816
Frequency: Continuous
Format: PDF and HTML
Versions: Online (Open Access)
Year first Published: 2018
Language: English

            Journal Menu
Editorial Board
Reviewer Board
Articles
Open Access
Special Issue Proposals
Guidelines for Authors
Guidelines for Editors
Guidelines for Reviewers 
Membership
Fee and Guidelines

Research on the Combination of Commercially Available Thickeners and Nutritional Supplemental Drink
-Aiming At the Care Food That Can Be Done In the General Family -

Shoko Kondo1, Megumi Oohashi1, Naomi Katayama2, 3*
1Watanabe Hospital, Noma, Aichi, Japan
2 Nagoya Women’s University, Nagoya City, 4678610, Japan
3Graduate School of Nagoya Women's University, Nagoya City, Japan

Received Date: 15 March, 2019; Accepted Date: 25 March, 2019; Published Date:  02 April, 2019
*Corresponding Author: Naomi Katayama, Nagoya Women’s University, Nagoya City, 4678610, Japan. And Graduate School of Nagoya Women's University, Nagoya City, Japan. E-mail: naomik@nagoya-wu.ac.jp

Citation: Kondo S, Oohashi M, Katayama N (2019) Research on the Combination of Commercially Available Thickeners and Nutritional Supplemental Drink -Aiming At the Care Food That Can Be Done In the General Family. Adv Nutri and Food Scie: ANAFS-127.


Abstract
      Background: Japan is currently a super-aged society with a percentage of people aged 65 and over exceeding 27.8%. According to the survey results of the Ministry of Health, Labor and Welfare, it was found that there were many elderly people who wanted to take care at home. It turned out that a total of 75.5%of the elderly wanted to receive family care or care services at home. Therefore, eating problems in home care are taken up a lot.

      Material and Methods: Food viscosity was tested using the line spread test (LST). Since commercial products differ in each maker, in order to adjust viscosity, it is necessary to adjust according to each maker’s instruction. A survey of viscosity control foods, thickeners and solidification supplements; nutraceuticals was conducted in the internet, pharmacy, and supermarkets. The available commercial food was actually purchased and the viscosity checked by LST.

      Results: As a result, we found 23 companies and 90 types (53 types of viscosity control food and 37 types of solidification supplements). Among them, we selected three types of viscosity control foods. Moreover, as for the commercial food which adjusted viscosity, the jelly was the six products and 13 types of taste, and the beverage was the seven products and 25 types of taste. Among them, we selected jelly foods and dietary supplement beverage that are also available to the general household. Food viscosity was tested using the line spread test (LST).It was found that when the food contains a large amount of protein and lipid, it is difficult to obtain viscosity depending on the compatibility with the thickener.

      Conclusion: The compatibility between the viscosity control food and the solidifying food supplement sold by each manufactures is good. When combining products from other companies, it is necessary to make adjustments and optimize in advance.


Keywords: Care food; Line spread test; Solidification supplement; Thickener; Viscosity adjustment food


 Introduction
    Japan is super aged society. According to the announcement of the recent Japanese Government, the ratio in the population of the elderly person of Japan is higher than 27.3% (15 million peoples male, 19.59 million people is female: 2016).The following three points are the issues brought about by the aging society. The first is a decline in the working age population. The second is the increase in social security costs. The last is an increase in the care burden. According to the survey results of the Cabinet Office in Japan, the majority of elderly societies want to spend their old age with their families. Especially for elderly people over 70, 59.8% would like to live with or close to their family. Also, according to the survey results of the Ministry of Health, Labor and Welfare, it was found that there were many elderly people who wanted to take care at home. It turned out that a total of 75.5%of the elderly wanted to receive family care or care services at home. Therefore, eating problems in home care are taken up a lot. It is necessary to provide reasonable care food by making good use of commercially available products. The Japanese Government performs a campaign to reduce a bedridden elderly person. Specifically, it is lifestyle improvement to postpone the healthy life expectancy of the elderly person. The Japanese Government wants to prevent Sarcopenia [1, 2] and Frailty [3-8] by the improvement of dietary habits and the exercise custom of the elderly person. We talk about the meal content to increase quantity of muscle of the elderly person. It is necessary to have the elderly person take in a meal with much protein9).However, the elderly person has the decline of the chewing function and the decline of the deglutition function. In addition, the elderly person has the person who cannot go for shopping far and wide every day. Therefore the protein which it is easy to eat which storable duration makes is necessary. The highly concentrated liquid food product is the food which it is easy to get and popular for a Japanese very much at drug stores. As for the highly concentrated liquid food product in particular, it is high protein, and it has many different kinds of flavours. In addition, various types of soft food have come to be sold in Japan. As for the soft food, there are various choices by a person eating from a little hard thing to a very soft thing. Therefore, the Japanese Society of Dysphagia Rehabilitation presented the swallowing adjustment food classification 2013as a guideline for the hardness of food. Food Companies have also begun selling Universal Design Food (UDF: indication the hardness of the food) so that more consumers can choose the right food. Furthermore, the elderly person cannot often take in a meal of much quantity at a time. Therefore, the elderly person need to eat rich-nutrition food which quantity is not so much. In addition, because the physical condition of the elderly changes daily, it is necessary to make the hardness of the diet tailored to each person. Many elderly people have problems with swallowing function. Even in water, viscosity adjustment is often required. Therefore, in this study, the compatibility between commercially available viscosity control food, thickener and solidifying supplement and nutraceutical was investigated using the line spread test (LST).


Material and Methods
Commercial Product Survey
      A survey of viscosity control foods, thickeners and solidification supplements, nutraceuticals was conducted in the internet, pharmacy, and supermarkets.

Viscosity Adjustment 

      The viscosity was adjusted to be used as a solidification supplement, nutraceutical, nutraceutical beverage, etc. using the selected viscosity-adjusting food and thickener. The adjustment method was performed based on each manufacturer’s instruction.

Line Spread Test (LST)

      The line spread test was performed using a simple viscosity test kit manufactured by Saraya. The inspection procedure is as follows.

  • Examine and adjust the food.
  • Put the viscosity adjustment plate on a flat place.
  • Place a ring of containing the food to be tested in the designated area of the viscosity test board (centre of the test board).
  • Put the food to be tested in the ring. Make sure that the entire amounts do not go out of the ring.
  • Let stand for 30 seconds.
  • Ring only, quietly pull up vertically. By this thing, the food spreads on the viscosity test board.
  • After 30 seconds, the spread of the food on the viscosity test board is recorded by reading the scale indicated on the test board. There are six scales to read.
  • The average of the six scales is recorded as the viscosity of the food to be measured.

Viscosity Evaluation

      The viscosity of each obtained food was classified according to the swallowing adjustment food classification 2013 proposed by the Japan Society of Dysphagia Rehabilitation. The classification is as follows.

  • Stage 1: Thin viscosity; 43-36 mm
  • Stage 2: Intermediate viscosity; 36-32 mm
  • Stage 3: Thick viscosity; 32-30 mm

     When the above three classifications do not apply, 43 mm or more was made very thin viscosity, and 30 mm or less was made very thick viscosity.


Results
Commercial Product Survey

      A survey of viscosity control foods, thickeners and solidification supplements, nutraceuticals was conducted in the internet, pharmacy, and supermarkets. As a result, we found 23 companies and 90 types (53 types of viscosity control food and 37 types of solidification supplements). Among them, we selected three types of viscosity control foods that are also available to the general household. (Table 1) shows the contents, prices and nutritional components of these three types of viscosity-adjusted food. The raw materials

of N company product and Ms Company product were dextrin, polysaccharide thickeners and pH adjusters. The raw materials of Ma company product were dextrin, xanthan gum, calcium lactate, tri-sodium citrate.

Product Name Taste Contents Price Nutritional Ingredients (per 100kg)
Energy (kcal) Protein (g) Fat (g) Carbohydrates (g) Salt Equivalent (g)
H Company Strawberry 63g 118 JY

(1 USD)

88 5 2 12.5 0.1
A Company Apple 130g 137 JY

(1.3 USD)

19 0 0 5.2 0.3
Ac Company Apple 10g 210  JY

(1.9 USD)

30 3 0 9.7 0.2
Ka Company

 

Peach 80g 103 JY (0.92 USD) 50 0 0 15.1 0~0 0.3
Grape 80g 103 JY (0.92 USD) 52 0 0 15.5 0.2
Apple 80g 103 JY (0.92 USD) 51 0 0 15.2 0~0 0.3
Me Company Pine Apple Yogurt 150ml 224 JY

(2 USD)

150 6 4.2 - -
Peach Yogurt 150ml 224 JY

(2 USD)

150 6 4.2 - -

Table 1: About selected viscosity adjustment food (thinker).

Viscosity Adjustment

       Moreover, as for the commercial food which adjusted viscosity, the jelly was the six products and 13 types of taste, and the beverage was the seven products and 25 types of taste. Among them, we selected jelly foods that are also available to the general household. (Table 2) shows the contents, prices and nutritional components of these three types of jelly food. And we selected dietary supplement beverage that are also available to the general household. (Table 3) shows the contents, prices and nutritional components of these three types of dietary supplement beverage.

 

Product Name Taste Contents Price Nutritional Ingredients (per 100kg)
Energy (kcal) Protein (g) Fat (g) Carbohydrates (g) Salt Equivalent (g)
H Company Strawberry 63 g 118 JY

(1 USD)

88 5 2 12.5 0.1
A Company Apple 130 g 137 JY

(1.3 USD)

19 0 0 5.2 0.3
Ac Company Apple 10 g 210  JY

(1.9 USD)

30 3 0 9.7 0.2
 

Ka Company

 

Peach 80 g 103 JY

(0.92 USD)

50 0 0 15.1 0~0 0.3
Grape 80 g 103 JY

(0.92 USD)

52 0 0 15.5 0.2
Apple 80 g 103 JY

(0.92 USD)

51 0 0 15.2 0~0 0.3
Me Company Pine Apple Yogurt 150 ml 224 JY

(2 USD)

150 6 4.2 - -
Peach Yogurt 150 ml 224 JY

(2 USD)

150 6 4.2 - -

 

Table 2: Selected jelly food (Commercial item used for line spread test (LST)).
 

Product Name Taste  

 

Contents

  Energy (Kcal) Nutritional Ingredients(per 100g)
 

Price

Proteins   (g) Fat

(g)

Carbohydrates (g) Salt Equivalent (g)
Mo Company Strawberry 125ml 177 JY

(1.6 USD)

200 7.5 6.7 29.3 0.28
Milk Tea 125ml 177 JY (1.6 USD) 200 7.5 6.7 29.3 0.28
Ke Company Strawberry 125ml 160 JY (1.4 USD) 200 7.5 7.5 25.6 -
Coffee 125ml 160 JY (1.4 USD) 200 7.5 7.5 25.6 -
Ke Company Fruit Mix 125ml 160 JY (1.4 USD) 200 7.5 7.5 25.6 -
Me Company

 

 

 

 

Blueberries 125ml 167 JY (1.5 USD) 200 7.5 5.6 31.7 0.28
White Peaches 125ml 167 JY (1.5 USD) 200 7.5 5.6 31.7 0.28
Strawberry 125ml 167 JY (1.5 USD) 200 7.5 5.6 31.8 0.28
Banana 125ml 167 JY (1.5 USD) 200 7.5 5.6 31.8 0.28
Yogurt 125ml 167 JY (1.5 USD) 200 7.5 5.6 31.8 0.28
Me Company Banana 125ml 240 JY (2.2 USD) 200 7.5 5.6 31.8 0.28
Me Company Fruit Mix 125ml 212JY (1.9 USD) 200 10 5.6 29.2 0.36
G Company Oranges 100ml 128 JY (1.2 USD) 44 0 0 12 0.01
Carrot & Apples 100ml 128 JY (1.2 USD) 45 0 0 12 0.03
Fruit Mix 100ml 128 JY (1.2 USD) 37 0 0 10 0.01

 

Table 3: Selected dietary supplement beverage (Commercial item used for line spread test (LST)). 

Line Spread Test (LST)

       In order to know the characteristics of each thickener, LST was first performed using water. The results are shown in (Table 4).The thickeners of each company showed almost the dame viscosity. The viscosity was about Stage 2: Intermediate viscosity; 36-32 mm.

 

Product Name

 

Line  Spread Test(mm)

LST Value

(Average)

1 2 3 4 5 6
Water 28 34 34 42 71 49 54.3
N Company+Water 35 36 35 34 34 35 35.4
Ma Company+Water 38 38 36 34 32 34 37.3
Mo Company+Water 30 31 32 32 31 31 31.7

Table 4: Result of line spread test (LST) thinker adjusted with water.

      Thirteen samples classified as jelly in the commercially available solidified supplements were tested without the addition of thickener. The results are shown in (Table 5). Similarly, 15 commercially available nutraceuticals, were also tested without the addition of thickener. The results are shown in (Table 6). Because the jelly-like food is solid or gel-like, the viscosity is thick at stage 2 or stage 3 or higher. However, the company A (apple taste), the company Ac (apple taste), the company Ka (Peach, grape, apple taste), was soft and thin viscous.

      Dietary supplement beverages were all liquid and had thin viscosity below stage 1or stage 1. These thin viscous products have been found to require the addition of thickeners tailored to the state of swallowing function.

Product Name Product Taste Line  Spread Test (mm) LST value
1 2 3 4 5 6 (Average)
H Company Strawberry 17 17 18 20 17 16 18.5
yogurt 15 17 15 17 15 15 16.6
A Company Apple 42 42 40 41 37 41 41.8
Ac Company Apple 42 43 41 37 40 40 42
Ka Company 40 41 35 34 36 35 39.3
Peach
Grape 42 40 37 41 39 39 41
Apple 40 41 40 36 33 38 40.3
Me Company Pine apple yogurt 29 28 31 30 31 31 31
Peach yogurt 31 30 27 30 32 31 31.3
Yogurt 32 32 31 33 34 33 33.3
Mo

Company

Honey yogurt 32 32 32 33 32 33 32.8
Banana yogurt 18 22 27 29 24 19 26.7
Grape yogurt 27 25 24 25 25 26 26.1

Table 5: Result of line spread test (LST) with selected jelly food.

 

Product Name

 

Product Taste

Line  Spread Test(mm) LST Value

(Average)

1 2 3 4 5 6
Mo Company Strawberry 53 58 52 53 54 54 55.3
Milk Tea 67 64 59 50 47 47 60
Ke Company Strawberry 60 63 54 50 52 55 59.6
Coffee 60 74 56 46 41 45 63.3
Ke Company Fruit Mix 61 62 57 52 53 58 60.3
 

Me Company

Blueberries 47 48 51 51 48 46 50.2
White Peaches 47 46 48 48 52 50 50.2
Strawberry 50 50 46 53 58 60 58
Banana 47 45 46 54 66 59 59.7
Yogurt 54 56 47 52 58 55 56.4
Me Company Banana 69 67 51 50 58 64 66.7
Me Company Fruit Mix 58 55 56 60 56 58 58.7
 

 

G Company

Oranges 48 50 49 53 54 45 52.3
Carrot & Apples 52 52 58 59 53 56 57.7
Fruit Mix 56 50 40 35 43 57 54.3

Table 6: Result of line spread test (LST) with selected dietary supplement beverage.

      Thickener N was added according to the instruction of use to a commercial product determined to require a thickener. The results are shown (Table 7and Table 8). Dietary supplements are high in protein. It was hard to get sticky overall. The tackiness may also be related to the lipid content.

 

Product Name

 

Product Taste

 

Line  Spread Test (mm)

 

LST Value

(Average)

1 2 3 4 5 6
A Company Apple 18 18 27 33 27 20 29
Ac Company Apple 19 21 26 33 28 21 29
Ka Company Peach 21 28 32 36 30 29 32.7
Grape 29 30 31 34 30 25 31.7
Apple 33 27 24 27 32 35 33.3

 

Table 7: Result of line spread test (LST) with selected jelly food with N Company thickener. 

 

Product Name

 

Product Taste

Line  Spread Test (mm)(Table 8) LST Value

(Average)

1 2 3 4 5 6
Mo Company Strawberry 60 63 51 45 57 51 58.6
Milk Tea 63 53 45 44 47 54 56.7
Ke Company Strawberry 59 66 56 50 46 48 60.3
Coffee 65 64 51 45 51 56 61.7
Ke Company Fruit Mix 55 50 49 49 59 64 59.3
 

Me Company

Blueberries 43 42 43 42 41 42 42.7
White Peaches 41 39 38 39 40 42 41
Strawberry 46 44 50 54 59 54 55.7
Banana 50 47 51 58 57 55 56.7
Yogurt 55 54 50 48 45 51 53.3
e Company Banana 63 68 55 46 47 50 62
Me Company Fruit Mix 46 46 45 43 43 43 45.7
 

 

G Company

Oranges 45 45 44 42 43 46 45.3
Carrot & Apples 48 49 47 46 46 48 48.3
Fruit Mix 45 43 43 44 49 49 47.8

 Table 8: Result of line spread test (LST) with selected dietary supplement beverages with N Company thickener.

Thickener Ma was added according to the instruction of use to a commercial product determined to require a thickener. The results are shown (Table 9 and Table 10). Dietary supplements are high in protein. It was hard to get sticky overall as same as thickener N. The tackiness may also be related to the lipid content.

Product Name Product Taste Line  Spread Test (mm) LST Value

(Average)

1 2 3 4 5 6
A Company Apple 19 25 25 26 23 20 25.3
Ac Company Apple 24 28 35 20 18 17 25.7
 

Ka Company

Peach 27 30 28 27 29 28 29.1
Grape 32 27 28 27 29 31 30.7
Apple 34 30 26 23 25 31 31.7

 

Table 9: Result of line spread test (LST) with selected jelly food with Ma Company thickener.

 

Product Name

 

Product Taste

Line  Spread Test (mm) LST Value

(Average)

1 2 3 4 5 6
Mo Company Strawberry 55 54 50 48 49 52 3.7
Milk Tea 60 55 51 48 49 54 56.3
Ke Company Strawberry 59 59 53 47 49 53 57.1
Coffee 58 61 54 47 48 50 57.7
Ke Company Fruit Mix 52 46 45 49 56 60 56
 

 

Me Company

Blueberries 24 24 27 30 30 31 30.3
White Peaches 31 29 21 19 20 28 29.3
Strawberry 48 47 47 52 54 52 52.7
Banana 47 48 52 53 54 50 53
Yogurt 47 50 50 46 46 47 49.2
Me Company Banana 54 54 53 49 50 52 53.7
Me Company Fruit Mix 37 38 40 40 39 37 39.7
 

 

G Company

Oranges 41 41 40 39 39 40 40.7
Carrot & Apples 36 37 36 34 34 35 36.3
Fruit Mix 36 39 40 38 36 35 39

Table 10: Result of line spread test (LST) with selected dietary supplement beverage with Ma Company thickener. 

       Thickener Mo was added according to the instruction of use to a commercial product determined to require a thickener. The results are shown (Table 11and Table 12). Dietary supplements are high in protein. It was hard to get sticky overall. The tackiness may also be related to the lipid content.

Product Name Product Taste Line  Spread Test (mm) LST Value

(Average)

1 2 3 4 5 6
A company Apple 22 24 28 26 20 20 26
Ac Company Apple 19 18 20 24 27 24 25
Ka Company Peach 29 30 30 28 27 27 29.7
Grape 25 21 24 28 35 31 31.3
Apple 33 30 24 22 24 30 31

Table 11: Result of line spread test (LST) with selected jelly food with Mo Company thickener.

Product Name Product Taste Line  Spread Test (mm) LST value

(Average)

1 2 3 4 5 6
Mo Company Strawberry 58 59 50 47 52 54 57
Milk Tea 58 56 54 52 51 52 56
K e Company strawberry 53 54 53 51 53 54 53.7
Coffee 54 54 52 49 50 49 53.3
K e Company Fruit Mix 54 44 53s 48 59 63 58.7
Blueberries 37 37 38 38 37 36 37.7
M e Company White Peaches 40 40 39 37 35 37 39.7
strawberry 43 44 51 53 60 50 54.7
banana 48 48 50 53 55 52 53.3
yogurt 49 49 47 48 49 47 49
M e Company banana 57 55 52 49 52 54 55.3
M e Company Fruit Mix 37 38 37 34 33 34 37.3
G Company Oranges 36 39 40 39 37 36 39.3
Carrot & Apples 41 44 43 40 38 39 42.7
Fruit Mix 36 39 40 39 37 36 39.3

Table 12: Result of line spread test (LST) with selected dietary supplement beverage with Mo Company thickener.
Viscosity Evaluation

      Determination of viscosity was made according to the swallowing adjustment food classification 2013 of the Japanese Society of Dysphagia Rehabilitation. All of the waters to which the three thickeners were added were in the classification of the society. The eight out of thirteen, jelly products were mostly in the academic category without the addition of thickeners. But five, jelly products need to add some thickeners within the classification of the society. In the case of a nutritional supplement beverage, even if it added a thickener, it was often thinner than the society classification. Products containing a large amount of protein and lipid are thickeners and do not stick easily. However, depending on the combination of the thickener and the product, it may be said that it is compatible because of its viscosity. This is because a product which had a viscosity thinner than that of the Society classification for Thickener N was recorded as a viscosity of Stage 1 of the Society classification for Thickeners Ma and Mo.


Discussion
      In this study, compared to water, beverages containing protein, lipids and sour fruit juice tend to be less sticky. When the viscosity is low, it is necessary to increase the amount of thickener, take time until the physical properties become stable after adding the thickener, and select and select the thickener suitable for the material. In addition, it was compatible with products sold by the same manufacturer and was easy to get sticky. It may take tens of seconds before the viscosity is obtained, so it is not necessary to check the viscosity while mixing, but a predetermined addition amount may be sufficiently mixed and evaluated in the optimized time, is necessary. Since the viscosity changes depending on the content of the food, it is necessary to confirm the viscosity in advance in the case of food and thickener used for the first time, if the concentration is low or high, it is a very dangerous food for people who are losing their swallowing function. As a result of performing the line spread test (LST) of the marketed product actually, there was a food which did not conform to the swallowing adjustment food classification of the Japan Dysphagia Rehabilitation Society. It is without saying that although LST alone ca not make a sufficient judgment, we will consider it a city that can be used as means to avoid danger. The viscosity needs to be tailored to the individual who consumes the food [10]. However, on the other hand, it has been reported that intake of viscous food induces abdominal bloating and may reduce the total intake of food [11]. In the present study, we adjusted the consistency at room temperature. Since the viscosity changes with temperature, it is necessary to consider the difference with temperature from now on. It is a future subject.


Conclusions
      In this research, we investigated the viscosity-adjusted food and the solidified supplement food that are marketed. Food viscosity was tested using the line spread test (LST). As for the commercial food which adjusted viscosity, the jelly was the six products and 13 types of taste, and the beverage was the seven products and 25 types of taste. Among them, we selected jelly foods that are also available to the general household. Since commercial products differ in each maker, in order to adjust viscosity, it is necessary to adjust according to each maker’s instruction. The compatibility between the viscosity control food and the solidifying food supplement sold by each manufactures is good. When combining products from other companies, it is necessary to make adjustments and optimize in advance. In this study, compared to water, beverages containing protein, lipids and sour fruit juice tend to be less sticky. When the viscosity is low, it is necessary to increase the amount of thickener, take time until the physical properties become stable after adding the thickener, and select and select the thickener suitable for the material. In addition, it was compatible with products sold by the same manufacturer and was easy to get sticky.

      In the present study, we adjusted the consistency at room temperature. Since the viscosity changes with temperature, it is necessary to consider the difference with temperature from now on. It is a future subject.


Acknowledgement
      This research was conducted by research and education expenses of Nagoya Women’s University Naomi Katayama, Nagoya City, Japan.


References 

  1. SilvaNeto LS, Karnikowiski MG, Tavares AB, Lima RM (2012) Association between sarcopenia, sarcopenic obesity, muscle strength and quality of life variables in elderly women. Rev. Bras Fisioter. 16: 360-367.
  2. Go SW, Cha YH, Lee JA, Park HS (2013) Association between Sarccopenia, Bone Density, and Health-Related Quality of life in Korean Men. Korean J Fam Med. 34: 281-288.
  3. Rizzoli R1, Reginster JY, Arnal JF, Bautmans I, Beaudart C, et al. (2013) Quality of life in sarcopenianad frailty. Calcif Tissue Int 93: 101-120.
  4. Fried LP, Ferrucci L, Darer J,   Williamson JD, Anderson G (2004) untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. JGerontolABiolSciMedSci. 59: 255-263.
  5. Ferrucci L1, Guralnik JM, Studenski S, Fried LP, Cutler GB Jr.et al (2004) designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report .J am GeriatrSoc. 52: 625-634.
  6. Bandeen-Roche K, Xue QL, Ferrucci L, Walston J, Guralnik JM, et al. (2006) Phenotype of frailty: characterization in the women's health and aging studies. J Gerontol A Biol Sci Med Sci. 61: 262-266.
  7. Fried LP, Tangen CM, Walston J (2001) Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: Evidence for a phenotype evidence for aphenotype. J Gerontol A BiolSci Med Sci. 56: 146-156.
  8. Ensrud KE1, Ewing SK, Taylor BC, Fink HA, Cawthon PM, et al. (2008) Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch InternMed. 168: 382-389.
  9. Malafarina V1, Uriz-Otano F, Iniesta R, Gil-Guerrero L (2013) Effectiveness of nutritional supplementation on muscle mass in treatment of sarcopenia in old age: a systematic review. J Am Med Dir Assoc 14: 10-17.
  10. Leder SB, Judson BL, Sliwinski E, Madson L (2013) Promoting safe swallowing when puree is swallowed without aspiration but thin liquid is aspirated: nectar is enough. Dysphagia 28: 58-62.
  11. Murray J1, Miller M, Doeltgen S, Scholten I (2014) Intake of thickened liquids by hospitalized adults with dysphagia after stroke. International Journal of Speech-Language Pathology 16: 486-494.